Bloodlines and Destiny Grids. Essentially, they are both the same thing: powers that transcend the fundamental nature of humanity.
Both of these methods allow a person to become stronger in the Inner Strengthening Realm, and the formations they condense later will also be stronger.
However, as Guangchen said, the foundation of a Divine Anomaly is the formation base... Having an extra one or two Divine Anomalies might be fine if they don't affect the formation, but if they disrupt the balance of the core formation diagram, the losses would outweigh the gains.
Chapter 295