Uchiha Chi knew very well that securing his position as Hokage required even more support and backing, so he intended to continue winning over Tsunade and Jiraiya. However, it would be much better for his plans if their relationship with Sarutobi Hiruzen deteriorated further first.
Guided by Uchiha Chi's deliberate maneuvers, Tsunade received the news the very moment she returned to Konohagakure. Enraged by Danzo's covert research into Hashirama's cells, she erupted into an unprecedented, fierce quarrel with the Third Hokage, Sarutobi Hiruzen.
Both sides dug in their heels, refusing to yield an inch. The atmosphere grew thick with hostility, instantly sparking a massive conflict. Had it not been for the tragic death of Namikaze Minato and his wife, which had plunged the entire Konohagakure into chaos, and had Tsunade not worried that her own radical actions might adversely affect the village, she likely would have left in anger once again.
Chapter 300